Look at your database's PortalAlias table. Next, look at your bindings for the IIS webste. The entry in PortalAlias must match the binding in IIS.

As you say that this is a local machine, I'd recommend that you do the initial install using nvQuickSite. That will get the PortalAlias and the IIS binding set up correctly. You can then compare that to your configuration.

Mostly those are hosting environement issues.
I would first check "Portals\_Default\Logs\2020.11.05.log.resources for errors

All tips here are good ones. Joe's suggestion about the connection string is the most common cause I see for that. I have a handy SQL script I use when restoring sites that I haven't previously restored in one of my environments. This is how I save time and prevent common issues like this one.

[code] /* Prepares a backed up client site for running locally. */ DECLARE @PortalID INT = 0; -- the PortalID for the above domain name (IMPORTANT for DNN instances that have multiple sites hosted) DECLARE @PortalAlias NVARCHAR(255) = N''; -- new domain name DECLARE @IsForLocalDev BIT = 1; -- 1 for installing locally, 0 for production-to-production, cloning, etc. BEGIN TRAN UPDATE [dbo].[PortalAlias] SET [IsPrimary] = 0 WHERE [PortalID] = @PortalID; IF NOT EXISTS(SELECT 1 FROM [dbo].[PortalAlias] WHERE [PortalID] = @PortalID AND [HttpAlias] = @PortalAlias) BEGIN INSERT INTO [dbo].[PortalAlias] ([PortalID],[HTTPAlias],[CreatedByUserID],[CreatedOnDate],[LastModifiedByUserID],[LastModifiedOnDate],[BrowserType],[IsPrimary]) VALUES (@PortalID,@PortalAlias,-1,GETDATE(),-1,GETDATE(),N'Normal',1); END ELSE BEGIN UPDATE [dbo].[PortalAlias] SET [IsPrimary] = 1 WHERE [PortalID] = @PortalID AND [HTTPAlias] = @PortalAlias; END UPDATE [dbo].[PortalSettings] SET [SettingValue] = @PortalAlias, [LastModifiedByUserID] = -1, [LastModifiedOnDate] = GETDATE() WHERE [PortalID] = @PortalID AND [SettingName] = N'DefaultPortalAlias'; IF NOT EXISTS (SELECT 1 FROM [dbo].[HostSettings] WHERE [SettingValue] = N'localhost') AND @IsForLocalDev = 1 BEGIN UPDATE [dbo].[HostSettings] SET [SettingValue] = 0, [LastModifiedByUserID] = -1, [LastModifiedOnDate] = GETDATE() WHERE [SettingName] = N'SMTPAuthentication'; UPDATE [dbo].[HostSettings] SET [SettingValue] = N'localhost', [LastModifiedByUserID] = -1, [LastModifiedOnDate] = GETDATE() WHERE [SettingName] = N'SMTPServer'; UPDATE [dbo].[HostSettings] SET [SettingValue] = N'N', [LastModifiedByUserID] = -1, [LastModifiedOnDate] = GETDATE() WHERE [SettingName] = N'SMTPEnableSSL'; END UPDATE [dbo].[Schedule] SET [Servers] = NULL WHERE NOT [Servers] IS NULL; COMMIT TRAN SELECT pa.* FROM [dbo].[PortalAlias] pa WHERE pa.[PortalID] = @PortalID ORDER BY pa.[CreatedOnDate]; SELECT ps.* FROM [dbo].[PortalSettings] ps WHERE [PortalID] = @PortalID AND [SettingName] = N'DefaultPortalAlias'; SELECT hs.* FROM [dbo].[HostSettings] hs WHERE hs.[SettingName] LIKE N'%SMTP%' ORDER BY hs.[SettingName]; SELECT s.* FROM [dbo].[Schedule] s WHERE NOT s.[Servers] IS NULL; /* END OF SCRIPT */ [/code]